[1]黄益麒,孙亚京,潘旭鸣,等.“痰瘀同治”方对多囊卵巢综合征模型大鼠胰岛素抵抗的作用[J].甘肃中医药大学学报,2016,33(01):17-20.[doi:10.16841/j.issn1003-8450.2016.01.05]
 HUANG Yiqi,SUN Yajing,PAN Xuming,et al.Effects of Tanyu Tongzhi Fang on insulin resistance in rats with polycystic ovary syndrome[J].Journal of Gansu University of Chinese Medicine,2016,33(01):17-20.[doi:10.16841/j.issn1003-8450.2016.01.05]
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“痰瘀同治”方对多囊卵巢综合征模型大鼠胰岛素抵抗的作用()
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
33卷
期数:
2016年01期
页码:
17-20
栏目:
实验研究
出版日期:
2016-02-25

文章信息/Info

Title:
Effects of Tanyu Tongzhi Fang on insulin resistance in rats with polycystic ovary syndrome
作者:
黄益麒1 孙亚京2 潘旭鸣1 黄平1
1. 浙江中医药大学第一临床医学院, 浙江 杭州 310053;
2. 浙江中医药大学第三临床医学院, 浙江 杭州 310053
Author(s):
HUANG Yiqi1 SUN Yajing2 PAN Xuming1 HUANG Ping1
1. The First Clinical Medical College, Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang, 310053, China;
2. The Third Clinical Medical College, Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang, 310053, China
关键词:
"痰瘀同治"方多囊卵巢综合征胰岛素抵抗胰岛素血糖性激素实验研究
Keywords:
Tanyu Tongzhi Fangpolycystic ovary syndrome (PCOS)insulin resistance (IR)insulinblood glucosesex hormonesexperimental research
分类号:
R285.5
DOI:
10.16841/j.issn1003-8450.2016.01.05
摘要:
目的 研究"痰瘀同治"方对多囊卵巢综合征模型大鼠胰岛素抵抗的作用。方法 采用硫酸普拉睾酮钠注射联合高脂饲料喂养诱导的造模方法制备伴胰岛素抵抗的多囊卵巢综合征大鼠模型,通过光镜计算卵巢排卵情况,测量空腹胰岛素(FINS)和血糖(FBG),并计算胰岛素敏感指数(ISI),采用放射免疫法测定性激素[血清睾酮(T)、雌二醇(E2)、促卵泡刺激素(FSH)和黄体生成素(LH)]的水平来评估"痰瘀同治"方对多囊卵巢综合征模型大鼠胰岛素抵抗的影响。结果 与对照组比较,模型组平均排卵数、排卵率及ISI、FSH均显著降低(P<0.01),血清T,E2和LH含量均显著升高(P<0.01),FBG,FINS显著升高,囊性扩张卵泡率显著增加(P<0.05);与模型组比较,治疗组平均排卵数及排卵率显著增加,ISI显著升高,FINS显著降低(P<0.01),血清T和E2含量均显著降低,FSH含量显著升高(P<0.05)。结论 "痰瘀同治"方对伴胰岛素抵抗的多囊卵巢综合征模型大鼠具有改善卵巢排卵障碍、增加胰岛素敏感性和降低性激素水平的作用。
Abstract:
Objective To observe the effects of Tanyu Tongzhi Fang on insulin resistance (IR) in rats with polycystic ovary syndrome (PCOS). Methods PCOS model rats with IR were brought up by injecting sodium prasterone sulfate and feeding high-fat diet. The ovulation, fasting insulin (FINS) and blood glucose (FBG) were measured through spectroscopic analysis, and expressions of sex hormones (serum T, E2, FSH and LH) were evaluated by radio-immune method. Results Compared with control group, in model group, average ovulation number and rate, ISI, FSH decreased (P<0.01);concentration of serum T, E2 and LH raised (P<0.01);FBG, FINS raised, cystic dilatation follicle rate increased (P<0.05). Compared with model group, in treatment group, average ovulation number and rate increased, ISI increased, FINS decreased (P<0.01);concentration of serum T, E2 decreased, FSH increased significantly (P<0.05). Conclusion Tanyu Tongzhi Fang can improve ovulation, increase the sensitivity of insulin and reduce the levels of sex hormones.

参考文献/References:

[1] Bhathena R K. Therapeutic options in the poIycystic ovary syndrome[J]. J Obstet Gynaecol,2007,27(2):123-129.
[2] 李琼. 补肾通脉方改善PCOS大鼠胰岛素抵抗和排卵障碍的分子机制研究[D]. 武汉:华中科技大学,2009.
[3] 李光伟,潘孝仁,Lillioja S,等. 检测人群胰岛素敏感性的一项新指数[J]. 中华内科杂志,1993(32):656-659.
[4] 史志刚,渠会莹. 从痰瘀脾虚论治胰岛素抵抗[J]. 疑难病杂志,2002,1(4):249-250.

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备注/Memo

备注/Memo:
收稿日期:2015-02-28
基金项目:2014年浙江省大学生科技创新活动计划(新苗人才计划)(2014R410009)。
作者简介:黄益麒(1991-),男,在读硕士研究生。研究方向:中医内科。
通信作者:黄平(1964-),男,教授,硕士生导师,医学博士。研究方向:中医药治疗内分泌疾病。E-mail:524677224@qq.com
更新日期/Last Update: 1900-01-01