[1]朱晓玉,刘雄,宋开蓉,等.板蓝根颗粒防潮辅料的筛选[J].甘肃中医药大学学报,2017,34(02):58-61.[doi:10.16841/j.issn1003-8450.2017.02.17]
 ZHU Xiaoyu,LIU Xiong,SONG Kairong,et al.Screening of damp-proofing excipients for Banlangen Keli[J].Journal of Gansu University of Chinese Medicine,2017,34(02):58-61.[doi:10.16841/j.issn1003-8450.2017.02.17]
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板蓝根颗粒防潮辅料的筛选
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
34卷
期数:
2017年02期
页码:
58-61
栏目:
工艺研究
出版日期:
2017-04-25

文章信息/Info

Title:
Screening of damp-proofing excipients for Banlangen Keli
作者:
朱晓玉1 刘雄1 宋开蓉1 师婷婷1 陈晖2 高建德1
1. 甘肃中医药大学药学院, 甘肃 兰州 730000;
2. 甘肃中医药大学教学实验中心, 甘肃 兰州 730000
Author(s):
ZHU Xiaoyu1 LIU Xiong1 SONG Kairong1 SHI Tingting1 CHEN Hui2 GAO Jiande1
1. Pharmacy College, Gansu University of Chinese Medicine, Lanzhou, Gansu, 730000, China;
2. Teaching and Research Center, Gansu University of Chinese Medicine, Lanzhou, Gansu, 730000, China
关键词:
板蓝根颗粒吸湿性数学模型防潮辅料筛选
Keywords:
Banlangen Kelihygroscopicitymathematical modeldamp-proofing excipientsscreening
分类号:
R283.2
DOI:
10.16841/j.issn1003-8450.2017.02.17
摘要:
目的 优选板蓝根颗粒的最佳防潮辅料,并选出与吸湿数据拟合后相关性最高的数学模型。方法 以板蓝根稠浸膏为模型药物,以吸湿性、成型性、外观变化和溶化性为考察指标,药辅比为1.0:1.5制粒考察单一辅料对颗粒吸湿性的影响,筛选出最佳防潮辅料,并测定临界相对湿度;对吸湿数据进行数学模型拟合,比较R2的大小,确定最佳吸湿数学模型。结果 单一辅料以药物:微晶纤维素(1.0:1.5)的防潮效果最好,并测得其临界相对湿度为80%;3种模型中R2值最高的是二次曲线方程,R2 ≥ 0.97,接近0.99。结论 筛选出的辅料能有效降低板蓝根颗粒的吸湿性,可用于工业化生产。
Abstract:
Objective To optimize the best damp-proofing excipients for Banlangen Keli,and also select the mathematical model with the highest correlation after fitting of moisture absorption data. Methods Banlangen Choujingao was used as model drug. Based on the evaluation indicators of hygroscopicity,formability,appearance change and dissolubility,the effect on hygroscopicity of single excipient was observed when the main-adjuvant formula was set at 1.0:1.5,then screened the best excipents and measured the critical relative moisture. After moisture absorption data fitting,the R2 values were compared to determine the best moisture absorption mathematical model.Results The main-adjuvant formula of 1.0:1.5 (main to microcrystalline cellulose) got the best hygroscopic effect. The critical relative moisture was 80%. The highest R2 value was in the quadratic curve equation among 3 models (R2 ≥ 0.97,closing to 0.99). Conclusion The screened excipient is effective in reducing hygroscopicity of Banlangen Keli,which can be applied to commercial production.

参考文献/References:

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[4] 李小芳,何倩灵,向永臣,等.黄芪多糖颗粒防潮辅料的研究[J].中国实验方剂学杂志,2011,17(9):11-14.
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备注/Memo

备注/Memo:
收稿日期:2016-06-27
作者简介:朱晓玉(1989-),女,在读硕士研究生。研究方向:中药有效成分与质量标准研究。
通信作者:刘雄(1963-),男,教授,硕士生导师,医学学士,主要从事中药有效成分与质量标准研究。E-mail:lx@gszy.edu.cn
更新日期/Last Update: 2017-07-11