[1]张一昕,王石红,韩雪,等.自拟疏肝健脾安神方治疗功能性消化不良伴焦虑、抑郁60例临床观察[J].甘肃中医药大学学报,2017,34(02):77-80.[doi:10.16841/j.issn1003-8450.2017.02.21]
 ZHANG Yixin,WANG Shihong,HAN Xue,et al.Clinical observation on 60 cases with functional dyspepsia accompanied by anxiety-depression treated by self-defined Shugan Jianpi Anshen Fang[J].Journal of Gansu University of Chinese Medicine,2017,34(02):77-80.[doi:10.16841/j.issn1003-8450.2017.02.21]
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自拟疏肝健脾安神方治疗功能性消化不良伴焦虑、抑郁60例临床观察
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
34卷
期数:
2017年02期
页码:
77-80
栏目:
临床研究与报道
出版日期:
2017-04-25

文章信息/Info

Title:
Clinical observation on 60 cases with functional dyspepsia accompanied by anxiety-depression treated by self-defined Shugan Jianpi Anshen Fang
作者:
张一昕1 王石红2 韩雪1 刘小发2 张睦清3 高玮4 王亚芬5
1. 河北中医学院药学院, 河北 石家庄 050091;
2. 河北省中医院脾胃病科, 河北 石家庄 050011;
3. 河北省中医院心血管科, 河北 石家庄 050011;
4. 河北省中医院药学部, 河北 石家庄 050011;
5. 河北医科大学研究生学院, 河北 石家庄 050011
Author(s):
ZHANG Yixin1 WANG Shihong2 HAN Xue1 LIU Xiaofa2 ZHANG Muqing3 GAO Wei4 WANG Yafen5
1. Pharmacy School, Hebei College of Chinese Medicine, Shijiazhuang, Hebei, 050091, China;
2. Spleen and Stomach Disease Section, Hebei TCM Hospital, Shijiazhuang, Hebei, 050011, China;
3. Cardiovascular Section, Hebei TCM Hospital, Shijiazhuang, Hebei, 050011, China;
4. Pharmacy Department, Hebbei TCM Hospital, Shijiazhuang, Hebei, 050011, China;
5. Graduate School, Hebei Medical University, Shijiazhuang, Hebei, 050011, China
关键词:
功能性消化不良焦虑抑郁自拟疏肝健脾安神方临床观察
Keywords:
functional dyspepsiaanxietydepressionself-definedShugan Jianpi Anshen Fangclinical observation
分类号:
R256.39
DOI:
10.16841/j.issn1003-8450.2017.02.21
摘要:
目的 观察自拟疏肝健脾安神方治疗功能性消化不良(FD)伴焦虑、抑郁的临床疗效。方法 将119例FD伴焦虑、抑郁的患者随机分为治疗组60例和对照组59例,2组分别给予自拟疏肝健脾安神方和西药治疗。用药4周后观察2组患者的主症改善情况和总体疗效,并评价汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)的评分情况。结果 治疗组总有效率(96.67%)高于对照组(83.05%)(P<0.05);2组患者的症状积分与同组治疗前比较均明显下降(P<0.01),且治疗组患者的早饱、嗳气和腹胀症状积分下降幅度均显著大于对照组(P<0.05);治疗组治疗后HAMA及HAMD评分较同组治疗前均明显下降(P<0.05),且HAMA评分下降幅度显著大于对照组(P<0.05)。结论 自拟疏肝健脾安神方治疗FD伴焦虑、抑郁效果显著,既能改善其主要症状,又能改善焦虑、抑郁状态,且未见不良反应发生,具有较高的临床运用及推广价值。
Abstract:
Objective To observe the therapeutic effect of self-defined Shugan Jianpi Anshen Fang (traditio-nal prescription aiming at liver soothing,spleen invigorating and spirit calming) in treating functional dyspepsia (FD) accompanied by anxiety-depression. Methods 119 FD patients with anxiety-depression were randomly divided into treatment group with 60 cases and control group with 59 cases. They were given self-defined Shugan Jianpi Anshen Fang and western medicine respectively. Clinical efficacy,Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) scores were examined after 4 weeks. Results The total effective rate of treatment group (96.67%) was higher than that of control group (83.05%) (P<0.05). The primary symptom scores of the two groups were obviously decreased than that of before (P<0.01),and the symptom scores of early satiety,eructation,abdominal distention in treatment group were higher than that in control group (P<0.05). HAMA and HAMD scores in treatment group declined obviously after treatment (P<0.05),and HAMA score of in treatment group was lower than that in control group (P<0.05). Conclusion Without any adverse reaction,the traditional prescription has a satisfying effect in treating FD with great improvement of the cardinal symptom and mental state. It possesses high value in clinical use and promotion.

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备注/Memo

备注/Memo:
收稿日期:2016-09-09
基金项目:河北省科技计划项目(142777112D)
作者简介:张一昕(1964-),男,教授,硕士生导师,医学博士,主要从事中药及其复方的临床研究。
更新日期/Last Update: 2017-07-11