[1]张琬婷,戴恩来,张禹,等.蛭龙通络胶囊联合西医常规治疗血瘀型慢性肾小球肾炎20例临床观察[J].甘肃中医药大学学报,2018,35(01):55-59.[doi:10.16841/j.issn1003-8450.2018.01.15]
 ZHANG Wanting,DAI Enlai,ZHANG Yu,et al.Clinical observation on Zhilong Tongluo Jiaonang combined with conventional western treatment for chronic glomerulonephritis with blood stasis[J].Journal of Gansu University of Chinese Medicine,2018,35(01):55-59.[doi:10.16841/j.issn1003-8450.2018.01.15]
点击复制

蛭龙通络胶囊联合西医常规治疗血瘀型慢性肾小球肾炎20例临床观察()
分享到:

《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
35卷
期数:
2018年01期
页码:
55-59
栏目:
临床研究与报道
出版日期:
2018-02-25

文章信息/Info

Title:
Clinical observation on Zhilong Tongluo Jiaonang combined with conventional western treatment for chronic glomerulonephritis with blood stasis
作者:
张琬婷1 戴恩来1 张禹1 薛国忠2 赵莉1 马丽1
1. 甘肃中医药大学中西医结合学院, 甘肃 兰州 730000;
2. 甘肃中医药大学附属医院肾病科, 甘肃 兰州 730020
Author(s):
ZHANG Wanting1 DAI Enlai1 ZHANG Yu1 XUE Guozhong2 ZHAO Li1 MA Li1
1. College of Chinese and Western Integrative Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, 730000, China;
2. Nephrology Department, Affiliated Hospital to Gansu University of Chinese Medicine, Lanzhou, Gansu, 730020, China
关键词:
慢性肾小球肾炎血瘀型蛭龙通络胶囊缬沙坦胶囊临床观察
Keywords:
chronic glomerulonephritissyndrome of blood stasisZhilong Tongluo JiaonangValsartan Capsulesclinical observation
分类号:
R277.523
DOI:
10.16841/j.issn1003-8450.2018.01.15
摘要:
目的 观察蛭龙通络胶囊联合西医常规治疗血瘀型慢性肾小球肾炎的临床疗效。方法 将40例血瘀型慢性肾小球肾炎患者随机分为治疗组与对照组,各20例。对照组给予西医常规治疗,治疗组在对照组治疗方法的基础上联合蛭龙通络胶囊治疗。2组均以4周为1个疗程,共治疗3个疗程。治疗3个疗程后比较2组治疗前后中医症状积分、尿蛋白含量、尿红细胞计数、24小时尿蛋白定量、血浆黏度、血小板聚集率及红细胞聚集指数,并比较2组的总临床疗效及中医证候疗效。结果 治疗组临床疗效总有效率及中医证候疗效总有效率分别为90%,85%,对照组分别为65%,75%,2组比较差异均有统计学意义(P<0.05);治疗组治疗后各中医症状积分均显著降低,对照组腰痛固定或刺痛积分显著降低,与同组治疗前比较,差异均有统计学意义(P<0.05),且治疗组各症状积分降低更显著(P<0.05);2组治疗后尿蛋白含量、尿红细胞计数、24小时尿蛋白定量、血浆黏度、血小板聚集率、红细胞聚集指数均显著降低,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组降低更显著(P<0.05)。结论 蛭龙通络胶囊可提高血瘀型慢性肾小球肾炎患者的临床疗效,并可减轻患者临床症状,改善各项实验室指标。
Abstract:
Objective To observe the curative effect of Zhilong Tongluo Jiaonang combined with conventional western treatment for chronic glomerulonephritis with the syndroeme of blood stasis.Methods 40 patinets of chro-nic glomerulonephritis were randomly divided into treatment group and control group,20 cases in each. The control group was treated with conventional western medicine,while the treatment group was intervened with Zhilong Tongluo Jiaonang in addition;4 weeks as 1 course,3 total courses in treatment. Indexes involving TCM symptomatic integrals,urinary protein,urinary red blood cell (URBC),24-hour urinary protein quantity,plasma viscosity,platelet aggregation rate (PAR) and aggregative index of red blood cell (AIRBC) were compared before and after treatment. Total effective rate and TCM symptom improvement were also compared between 2 groups.Results The total effective rates and TCM syndrome effective rates were 90%,85% in treatment group,while 65%,75% in control group,the differenc was significant (P<0.05);after treatment,TCM symptomatic integrals of 2 groups decreased obviously,while changed more in treatment group,there were differences (P<0.05). All indexes in 2 groups dropped apparently after treatment,while dropped more in treatment group,the differences were all statistically significant (P<0.05).Conclusion Zhilong Tongluo Jiaonang has notalbe curative effect in treating chronic glomerulonephritis with alleviation of symptoms and improvement of test indexes.

参考文献/References:

[1] 唐盛.慢性肾脏病流行病学调查研究进展[J].中国临床新医学,2011,4(5):478-481.
[2] 戴恩来.刘宝厚教授运用血液流变学检测方法诊治肾脏病的经验[J].中国中西医结合肾病杂志,2005,6(12):685-686.
[3] 陈香美.临床诊疗指南·肾脏病学分册[M].北京:人民卫生出版社,2010:12.
[4] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:376-377.
[5] 中华医药学会肾病分会.慢性肾小球肾炎的诊断、辨证分型及疗效评定[J].上海中医药杂志,2006(6):8-9.
[6] 于敏,张波,史耀勋,等.南征教授"毒损肾络"理论学说探析及临床运用[J].中华中医药学刊,2010(2):243-246.
[7] 刘芳,王耀光.从中医"毒损肾络"理论探讨乙肝病毒相关性膜性肾炎机制假说[J].中医药通报,2012,11(3):38-40.
[8] 戴恩来.慢性肾脏病"毒损肾络"病机概论[J].中国中西医结合肾病杂志,2014,15(2):97-100.
[9] 吴瑛,任安乐.大鼠脑出血急性期给予水蛭素后血肿周围组织胶质纤维酸性蛋白的表达[J]. 兰州大学学报(医学版),2009,35(1):1-4.
[10] 黄震华.新型抗凝和抗血小板新药——重组水蛭素[J].中国新药与临床杂志,2003,22(5):309-312.
[11] 董柯,陈香美,汤力.水蛭对系膜增殖性肾炎蛋白尿、脂质代谢及凝血机制的影响[J].中华内科杂志,1995,34(4):250-252.
[12] 李昭永,胡贤琼.水蛭在治疗肾小球性蛋白尿中的应用[J].中医研究,2002,15(2):33-34.
[13] 何执中,郭怀芳,唐宁,等.蚯蚓纤溶酶的分离纯化及抗栓活性研究[J].中国生化药物杂志,2001,22(6):284-286.
[14] 马艳春,周波,宋立群,等.地龙成分及含药血清对人正常肾小球系膜细胞增殖的影响[J].中国临床保健杂志,2010,13(5):493-495.

相似文献/References:

[1]王振亚.从虚论治慢性肾小球肾炎研究进展[J].甘肃中医药大学学报,2015,32(01):61.
[2]李建省,戴恩来,孙红旭.试述慢性肾小球肾炎的证治规律[J].甘肃中医药大学学报,2006,(02):7.
[3]刘清华,曾昭洋.中医药治疗血瘀型腰椎间盘突出症48例[J].甘肃中医药大学学报,2006,(06):18.
[4]胡翀妮.穴位埋线周期疗法配合艾灸治疗血瘀型原发性痛经38例临床观察[J].甘肃中医药大学学报,2017,34(04):83.[doi:10.16841/j.issn1003-8450.2017.04.24]
[5]麻志恒,施志琴,张汉新,等.抗纤灵汤治疗血瘀型慢性肾功能衰竭34例临床观察[J].甘肃中医药大学学报,2017,34(06):44.[doi:10.16841/j.issn1003-8450.2017.06.13]
 MA Zhiheng,SHI Zhiqin,ZHNAG Hanxin,et al.Clinical observation of Kangxianling Tang in treating chronic renal failure due to blood stasis on 34 cases patients[J].Journal of Gansu University of Chinese Medicine,2017,34(01):44.[doi:10.16841/j.issn1003-8450.2017.06.13]

备注/Memo

备注/Memo:
收稿日期:2017-5-24。
基金项目:2015年甘肃中医药大学研究生创新基金项目(2016CX12)。
作者简介:张琬婷(1990-),女,在读硕士研究生。研究方向:中西医结合防治肾病。
通信作者:戴恩来(1963-),男,教授,主任医师,博士生导师,医学博士。研究方向:中西医结合防治肾病。E-mail:del@gszy.edu.cn
更新日期/Last Update: 1900-01-01