[1]许益国.血清TNF-α,IL-6,IL-10联合检测在小儿大叶性肺炎中临床意义的研究[J].甘肃中医药大学学报,2018,35(01):60-62.[doi:10.16841/j.issn1003-8450.2018.01.16]
 XU Yiguo.Clinical value of joint detection of serum TNF-α,IL-6 and IL-10 in children with lobar pneumonia[J].Journal of Gansu University of Chinese Medicine,2018,35(01):60-62.[doi:10.16841/j.issn1003-8450.2018.01.16]
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血清TNF-α,IL-6,IL-10联合检测在小儿大叶性肺炎中临床意义的研究()
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《甘肃中医药大学学报》[ISSN:1003-8450/CN:62-1062/R]

卷:
35卷
期数:
2018年01期
页码:
60-62
栏目:
临床研究与报道
出版日期:
2018-02-25

文章信息/Info

Title:
Clinical value of joint detection of serum TNF-α,IL-6 and IL-10 in children with lobar pneumonia
作者:
许益国
庆阳市中医医院检验科, 甘肃 庆阳 745000
Author(s):
XU Yiguo
Clinic Lab, Qingyang TCM Hospital, Qingyang, Gansu, 745000, China
关键词:
大叶性肺炎小儿肿瘤坏死因子-α白细胞介素-6白细胞介素-10诊断
Keywords:
lobar pneumoniachildrenTNF-αIL-6IL-10diagnosis
分类号:
R563.1+1
DOI:
10.16841/j.issn1003-8450.2018.01.16
摘要:
目的 观察大叶性肺炎患儿血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、IL-10含量的变化,探讨以上指标在小儿大叶性肺炎诊断及病情评估中的意义。方法 选取庆阳市中医医院儿科2015年6月至2016年12月收治的大叶性肺炎患儿90例和同期健康体检儿童78例作为研究对象,依据临床肺部感染评分(CPIS)将大叶性肺炎患儿分为轻度组(n=43)和重度组(n=47),比较对照组和大叶性肺炎组、大叶性肺炎轻度组和大叶性肺炎重度组患儿血清TNF-α,IL-6,IL-10含量。结果 与对照组比较,大叶性肺炎组血清TNF-α,IL-6,IL-10含量明显升高,差异均有统计学意义(P<0.01);与大叶性肺炎轻度组比较,大叶性肺炎重度组患儿血清TNF-α,IL-6,IL-10含量显著升高,差异均有统计学意义(P<0.05)。结论 血清细胞因子TNF-α,IL-6,IL-10联合检测在小儿大叶性肺炎的诊断、病情评估中具有重要的临床意义。
Abstract:
Objective To observe the changes of serum contents of TNF-α,IL-6 and IL-10 in children with lobar pneumonia and to explore their clinical value in diagnosing the disease and accessing condition.Methods 90 pediatric patients with lobar pneumonia and 78 healthy children were enrolled in the pediatric department from June 2015 to December 2016. According to the clinical pulmonary infection score (CPIS),children with lobar pneumonia were divided into mild group (n=43) and severe group (n=47). 78 healthy children was set as contol group. Contents of TNF-α,IL-6,IL-10 in mild group,severe group and control group were compared.Results Compared with control group,the contents of serum TNF-α,IL-6 and IL-10 in two lobar pneumonia groups were obviously increased,the difference was significant (P<0.01). Compared with mild group,the contents of serum TNF-α,IL-6 and IL-10 in severe group were also clearly increased,the difference was statistically significant (P<0.05).Conclusion Joint detection of serum cytokines contents of TNF-α,IL-6 and IL-10 has important clinical significance in the diagnosis and assessment for children with lobar pneumonia.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2017-3-8。
作者简介:许益国(1984-),男,主管检验师,医学学士,主要从事临床医学检验工作。
更新日期/Last Update: 1900-01-01